https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525017/
Oxidative stress caused by reactive oxygen species is considered a major mediator of tissue and cell injuries in various neuronal conditions, including neurological emergencies and neurodegenerative diseases. Molecular hydrogen is well characterized as a scavenger of hydroxyl radicals and peroxynitrite. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported in both basic and clinical settings. Here, we review the effects of hydrogen therapy in acute neuronal conditions and neurodegenerative diseases. Hydrogen therapy administered in drinking water may be useful for the prevention of neurodegenerative diseases and for reducing the symptoms of acute neuronal conditions.
Keywords: hydrogen, central nervous system, neurodegenerative disease, oxidative stress, neuroinflammation
Control of oxidative stress is a major therapeutic strategy for various neuronal conditions
Metabolic syndrome is a strong risk factor of stroke. It has been reported that H2 therapy can improve metabolic syndrome in basic and clinical settings.(24–27) H2 therapy may reduce stroke in patients with metabolic syndrome involving diabetes mellitus.
The therapeutic effect of H2-rich water following TBI and in posttraumatic onset of Alzheimer’s disease (AD) was investigated by Dohi et al. in 2014,(18) who investigated whether the consumption of H2-rich water 24 h prior to trauma can inhibit neuronal damage in a controlled cortical injury model using mice. The authors found that the expression of the phosphorylated tau proteins AT8 and Alz50 in the hippocampus and cortex was blocked in mice that consumed H2-rich water. Moreover, the activity of astrocytes and microglia were inhibited in mice TBI model consuming H2-rich water.
The consumption of H2-rich water influenced the production of cytokines and chemokines in the damaged brain and inhibited the production of hypoxia inducible factor-1 (HIF-1), MMP-9, and cyclophilin
It is known that stress causes nerve cell impairments.(43) The consumption of H2-rich water inhibits oxidative stress and thereby inhibits the onset of stress-induced brain damage.(43)
With the consumption of H2-rich-water-drinking, oxidative stress in the nigrostriatal pathway was inhibited and loss of dopamine cells was decreased. These results suggest that consuming H2-rich water could affect the onset of PD. In recent years, the results of a clinical trial on the effects of consuming H2-rich water for PD have been reported.(49) A randomized double-blind study showed that consuming H2-rich water (1,000 ml/day) for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) score of PD patients treated with levodopa. A double-blind multi-center trial of H2 water is currently underway (Table 1).(50)
ALZHEIMER
consumption of H2-rich water prevents neurodegenerative disease and that H2-rich drinking water could be used to treat acute brain disorder
Unlike more conventional drugs, H2 treatment, particularly the consumption of H2-rich water, has no known serious side effects and is effective for preventing the onset of neurodegenerative disease and aggravation of acute neuronal conditions.